A Direct Current Polarographic Method for the Determination of Chlorpheniramine Maleate in Pharmaceutical Preparations

A direct polarographic method for the determination of chlorpheniramine maleate in pharmaceutical preparations had been developed. The method was based on the reduction of chlorpheniramine maleate in an acidic medium (pH 1.2-4.0). The effect of pH on the polarographic wave was investigated by recording d.c. polarograms in various supporting electrolytes. The calibration graphs were rectilinear for 5 to 20 g ml-1 of chlorpheniramine maleate in 0.1 mol L-1 hydrochloric acid pH 1.2, chloride buffer pH 2.0 and phthalate buffer pH 4.0 respectively. The method was simple and rapid, results being reproducible within ±2.53% (in 0.1 mol L-1 hydrochloric acid or chloride buffer pH 2.0), and ±1.06% (in phthalate buffer pH 4.0) for 10 determinations respectively. The method was applicable to the analysis of chlorpheniramine maleate in tablets, syrup and injection. There was no interference from acetaminophen, phenylpropanolamine hydrochloride and ascorbic acid.